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energy expenditure 3

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Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation

Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 68-74 doi: 10.1007/s11684-022-0955-9

Abstract: Furthermore, CGI was significantly associated with various parameters such as insulin sensitivity/secretionshowed that the disposition index, which reflects β-cell function after adjusting for insulin

Keywords： complexity of glucose time series continuous glucose monitoring impaired glucose regulation insulinsecretion and sensitivity refined composite multi-scale entropy

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventiveeffect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic

Keywords： palmitate characteristic study plasma resistance

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Mechanism of insulin resistance in obesity: a role of ATP

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 372-382 doi: 10.1007/s11684-021-0862-5

Abstract: Obesity increases the risk of type 2 diabetes through the induction of insulin resistance.The mechanism of insulin resistance has been extensively investigated for more than 60 years, but theThe ATP production is elevated in insulin-sensitive cells under obese conditions independent of energyInsulin resistance cuts down the substrate uptake to attenuate mitochondrial overloading.The prevention of ATP overproduction represents a key strategy for insulin sensitization.

Keywords： type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract:

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistancealthough there have been several well-documented hypotheses for insulin resistance.resistance, in which insulin resistance is a result of energy surplus in cells., which may apply to insulin resistance in aging and lipodystrophy.

Keywords： type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase (AMPK)

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract:

Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causesThe BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletalmuscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiencyAlthough increased circulating BCAA concentration in insulin resistant conditions has been noted for

Keywords： branched-chain amino acids leucine isoleucine valine insulin resistance

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Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 403-407 doi: 10.1007/s11684-009-0071-0

Abstract: This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-α in high-fat diet-induced insulin-resistant rats.Changes of body weight, lipid profile, and fasting plasma glucose and insulin were measured.The insulin sensitivity index (ISI) was calculated.In conclusion, exercise training ameliorates insulin resistance.

Keywords： exercise training insulin resistance tumor necrosis factor-α

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: Oral insulin delivery has received the most attention in insulin formulations due to its high patientcompliance and, more importantly, to its potential to mimic the physiologic insulin secretion seen inHowever, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulinIn vitro studies demonstrated that the CPP-insulin conjugates could facilitate cellular uptake of insulinwhile keeping insulin’s biologic functions intact.

Keywords： insulin cell penetrating peptide mucoadhesive composites oral delivery

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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulinThe primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR).Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.

Keywords： insulin resistance non-alcoholic fatty liver disease Chinese herbal medicine randomized controlled

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Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis

Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 72-88 doi: 10.1007/s11705-016-1580-4

Abstract: The results suggest that the proteins encoded by PqqB, B932_1930 and B932_2186 might enhance the PQQ secretion

Keywords： 2D-DIGE pqqB pyrroloquinoline quinone RNA-Seq Vitamin C

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: This study aims to investigate the influence of β-elemene on the secretion of angiotensin II (ANG II)The secretion of ANG II in the supernatant was detected by radioimmunoassay.At the 4th h, the ANG II secretion in the supernatant was significantly inhibited by 10 mg/L β-elemeneAt the time point of the 12th h, the secretion of ANG II in the supernatant treated with 10 mg/L andAT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene can inhibit the secretion

Keywords： liver cirrhosis beta-elemene hepatic stellate cells angiotensin II receptor angiotensin type 1

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Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: The objective of this study was to investigate the effects of resistin on insulin signaling in humanendothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basal or insulincould significantly inhibit Akt and eNOS phosphorylation and NO production in endothelial cells under insulinThese findings suggested that resistin exerted an inhibitory effect on NO production by inhibiting insulin

Keywords： resistin endothelium nitric oxide endothelial nitric oxide synthase Akt-binding protein mouse

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A Smart Pill for Insulin?

Elizabeth K. Wilson

Engineering 2019, Volume 5, Issue 4, Pages 603-604 doi: 10.1016/j.eng.2019.07.008

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract: Insulin resistance associated with central obesity is the major cause of hepatic steatosis, which is

Keywords： nonalcoholic fatty liver disease insulin resistance obesity

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Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: It was concluded that gene polymorphism at TNF-α-308 sites may relate to the secretion of TNF-αTP has different inhibitory effects on the secretion of TNF-α in the patients harboring different

Keywords： arthritis rheumatoid molonuclear cells tumor necrosis factor gene polymorphisms triptolid

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Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract: roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulinstorage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action.

Keywords： zinc zinc transporters metallothionein diabetes diabetic complications insulin resistance antioxidant

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Title Author Date Type Operation

Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventiveeffect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Mechanism of insulin resistance in obesity: a role of ATP

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,